The biology of the immunoregulatory cytokines IFNγ, IL-18, and IL-22

H. Mühl (group leader), M. Bachmann (staff scientist), S. Gonther (PhD student), P. Frano (MD student)

Most diseases accompanied with inflammation, autoimmunity, and infection are associated with changes in cytokine, chemokine, and growth factor production. We investigate roles of these mediators related to the processes of inflammation and carcinogenesis.

In particular, we study the biology of cytokines and mediators that are associated with Th1-like inflammation with focus on IFNγ, IL-22, the IL-1 family of cytokines, and nitric oxide.

Supported by DFG (DFG MU 1284/6-1)
und GRK 2336: AVE - Resolution of Inflammation

Full publication list of Heiko Mühl: or

Selected Original Publications

Bachmann M, Pfeilschifter J, and Mühl H. A prominent role of IL-18 in acetaminophen-induced liver injury advocates its blockage for therapy of hepatic necroinflammation. Front Immunol, 2018 (in press)

Bachmann M, Waibler Z, Pleli T, Pfeilschifter J and Mühl H. Type I interferon supports inducible nitric oxide synthase in murine hepatoma cells and hepatocytes and during experimental acetaminophen-induced liver damage. Front Immunol. 2017 Jul 31;8:890. doi: 10.3389/fimmu.2017.00890. eCollection 2017.

Chichelnitskiy E, Himmelseher B, Bachmann M, Pfeilschifter J, and Mühl H. Hypothermia promotes IL-22 expression and fine-tunes its biological activity. Front Immunol.8: 742, 2017

Bachmann M, Meissner C, Pfeilschifter J, and Mühl, H. Cooperation between the bacterial-derived short-chain fatty acid butyrate and interleukin-22 detected in human Caco2 colon epithelial/carcinoma cells. Biofactors, 43(2): 283-292, 2017

Berner A, Bachmann M, Bender C, Pfeilschifter J, Christen U and Mühl H. Though Active on RINm5F Insulinoma Cells and Cultured Pancreatic Islets, Recombinant IL-22 Fails to Modulate Cytotoxicity and Disease in a Protocol of Streptozotocin-Induced Experimental Diabetes. Front Pharmacol., 6: 317, 2016

Härdle L, Bachmann M, Bollmann F, Pautz A, Schmid T, Eberhardt W, Kleinert H, Pfeilschifter J, and Mühl, H. Tristetraprolin regulation of interleukin-22 production. Sci Rep., 5: 15112, 2015.

Scheiermann P, Bachmann M, Härdle L, Pleli T, Piiper A, Zwissler B, Pfeilschifter J, and Mühl H. Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injury.
Sci Rep., 5: 8521, 2015.

Scheiermann P, Bachmann M, Goren I, Zwissler B, Pfeilschifter J, and Mühl H. Application of interleukin-22 mediates protection in experimental acetaminophen-induced acute liver injury. Am J Pathol., 182(4):1107-13, 2013

Bachmann M, Ulziibat S, Härdle L, Pfeilschifter J, and Mühl H. IFNa converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets. Biochem Pharmacol., 85(3): 396-403, 2013

Bachmann M, Scheiermann P, Härdle L, Pfeilschifter J, and Mühl H. IL36γ/IL1F9 - an innate T-bet target in myeloid cells.
J Biol Chem., 287(50): 41684-96, 2012

Bachmann M, Horn K, Rudloff I, Goren I, Holdener M, Christen U, Darsow N, Hunfeld KP, Koehl U, Kind P, Pfeilschifter J, Kraiczy P, and Mühl H. Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and IL-1. PLoS Pathogens, 14;6(10):e1001144, 2010

Sadik CD, Bachmann M, Pfeilschifter J, and Mühl H. Activation of interferon regulatory factor-3 via Toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA. Nucleic Acids Res, 37(15):5041-56, 2009

Bachmann M, Paulukat J, Pfeilschifter J, and Mühl H. Molecular mechanisms of IL-18BP regulation in DLD-1 cells: pivotal direct action of the STAT1/GAS axis on the promoter level.
J Cell Mol Med, 2009, 13(8B), 1987-1994

Ziesché E, Bachmann M, Kleinert H, Pfeilschifter J, Mühl H. The IL-22/STAT3 pathway potentiates expression of iNOS in human colon carcinoma cells. J Biol Chem, 2007, 282(22), 16006-16015

Paulukat J, Bosmann M, Nold M, Garkisch S, Kämpfer H, Frank S, Raedle J, Zeuzem S, Pfeilschifter J, Mühl H. Expression and release of IL-18 binding protein in response to Interferon-g.
J Immunol 2001 Dec;167(12):7038-7043.

Recent Reviews

Mühl, H. STAT3, a key parameter of cytokine-driven tissue protection during sterile inflammation – the case of experimental acetaminophen (paracetamol)-induced liver damage. Front Immunol. 7: 163, 2016

Mühl H, Scheiermann P, Bachmann M, Härdle L, Heinrichs A, and Pfeilschifter J. IL-22 in tissue protective therapy. Br J Pharmacol, 169(4): 761-71. 2013

Mühl, H. Pro-Inflammatory Signaling by IL-10 and IL-22: Bad Habit Stirred up by Interferons? Front. Immunol, 2013; 4: 18, doi: 10.3389/fimmu.2013.00018

Mühl H, Bachmann M and Pfeilschifter J. Inducible NO synthase and antibacterial host defense
in times of Th17/Th22/T22 immunity. Cell Microbiol, 13(3):340-8, 2011

Mühl H, Pfeilschifter J. Interleukin-18 bioactivity: a novel target for immunopharmacological anti-inflammatory intervention.
Eur J Pharmacol. 2004 Oct 1;500(1-3):63-71

Mühl H, Pfeilschifter J. Anti-inflammatory properties of pro-inflammatory interferon-gamma.
Int Immunopharmacol. 2003 Sep;3(9):1247-55

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Sekretariat Prof. Dr. Josef Pfeilschifter

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