Publications 2017

  1. Goren I, Lee SY, Maucher D, Nüsing R, Schlich T, Pfeilschifter J, and Frank S. Inhibition of cyclooxygenase-1 and -2 activity in keratinocytes inhibits PGE2 formation and impairs VEGF release and neovascularization in skin wounds.Int Wound J., 14: 53-63, 2017

  2. Frey H, Moreth K, Hsieh LTH, Zeng-Brouwers J, Rathkolb B, Fuchs H, Gailus-Durner V, Iozzo RV, Hrabě de Angelis M, and Schaefer L. A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia. Glycoconj J., 34(3): 393-404, 2017

  3. Schaefer L, Tredup C, Gubbiotti M, and Iozzo RV. Proteoglycan neofunctions: Regulation of inflammation and autophagy in cancer biology. FEBS J 284: 10-26, 2017

  4. Bender C, Christen S, Scholich K, Bayer M, Pfeilschifter JM, Hintermann E, and Christen U. Islet-expressed CXCL10 Promotes Autoimmune Destruction of Islet Iso-Grafts in Mice with Type 1 Diabetes. Diabetes. 66(1): 113-126, 2017

  5. Didiasova M, Singh R, Kwapiszewska G, Wujak L, Zakrzewicz D, Markart P, Seeger W, Schaefer L, Lauth M, and Wygrecka M. Pirfenidone exerts anti-fibrotic effects through a direct inhibition of GLI transcription factors. FASEB J 31: 1916-1928, 2017

  6. Martin J, Radeke HH, Dignass A and Stein J. Curent evaluation and management of anaemia in patients with inflammatory bowel disease. Expert Rev Gastroenterol Hepatol., 11(1): 19-32, 2017

  7. Wygrecka M, Kosanovic D, Zakrzewicz D, Hess R, Henneke I, Didiasova M, Wujak L, Baal N, Hackstein H, Reppe K, Müller-Redetzky HC, Witzenrath M, de Maat S, Maas C, Nolte MV, Panousis C, Ralph T. Schermuly RT, Schaefer L, and Markart P. C1 esterase inhibitor protects against histone-mediated lung injury. Am J Respir Crit Care Med., 196: 186-199, 2017

  8. Friedländer F, Bohmann F, Brunkhorst M, Chae JH, Devraj K, Köhler Y, Kraft P, Kuhn H, Lucaciu A, Luger S, Pfeilschifter W, Sadler R, Liesz A, Scholtyschik K, Stolz L, Vutukuri R, and Brunkhorst R. Reliability of infarct volumetry: Its relevance and the improvement by a software-assisted approach. J Cereb Blood Flow Metab., 37(8): 3015-3026, 2017

  9. Frölich S, Slattery P, Thomas D, Goren I, Ferreiros N, Jensen BL, and Nüsing RM. Angiotensin II-AT1-receptor signaling is necessary for cyclooxygenase-2-dependent postnatal nephron generation. Kidney Int., 91: 818-829, 2017

  10. Bachmann M, Meissner C, Pfeilschifter J, and Mühl, H. Cooperation between the bacterial-derived short-chain fatty acid butyrate and interleukin-22 detected in human Caco2 colon epithelial/carcinoma cells. Biofactors, 43(2): 283-292, 2017

  11. Badawi A, Hehlgans S, Pfeilschifter J, Rödel F and Eberhardt W. Silencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of caspase-2. Cancer Lett., 393: 103-112, 2017

  12. Ball AK, Beilstein K, Wittmann S, Sürün D, Saul M, Schnütgen F, Flamand N, Capelo R, Kahnt AS, Frey H, Schaefer L, Marschalek R, Häfner AK, Steinhilber S. Characterization and cellular localization of human 5lipoxygenase and its protein isoforms 5-LOΔ13, 5-LOΔ4 and 5-LOp12. Biochim Biophys Acta 1862: 561-571, 2017

  13. Slattery P, Frölich S, Goren I, and Rolf Nüsing. Salt supplementation ameliorates developmental kidney defects in COX-2-/- mice. American Journal of Physiology - Renal Physiology, 312(6):F1044-F1055, 2017

  14. Hsieh LTH, Nastase MV, Roedig H, Zeng-Brouwers J, Poluzzi C, Schwalm S, Fork C, Tredup C, Brandes RP, Wygrecka M, Huwiler A, Pfeilschifter J, and Schaefer L. Biglycan- and sphingosine kinase1-signaling crosstalk regulates the synthesis of macrophage chemoattractants. Int J Mol Sci , 18, 595; doi:10.3390/ijms18030595, 2017

  15. Imre G, Berthelet J, Heering J, Kehrloesser S, Melzer IM, Lee BI, Thiede B, Dötsch V, and Rajalingam K. Apoptosis inhibitor 5 is an endogenous inhibitor of caspase-2. EMBO Rep., 18(5):733-744, 2017

  16. Nastase MV, Janicova A, Wygrecka M, and Schaefer L. Signaling at the crossroads: Matrix-derived proteoglycan- and reactive oxygen species signaling. Antioxid Redox Signal, 27: 855-873, 2017

  17. Wujak L, Hesse C, Sewald K, Jonigk D, Braubach P, Warnecke G, Fieguth HG, Braun A, Lochnit G, Markart P, Schaefer L, and Wygrecka M. FXII promotes proteolytic processing of the LRP1 ectodomain. Biochim Biophys Acta Gen Subject 1861: 2088-2098, 2017

  18. Chichelnitskiy E, Himmelseher B, Bachmann M, Pfeilschifter J, and Mühl H. Hypothermia promotes IL-22 expression and fine-tunes its biological activity. Front Immunol.8: 742, 2017

  19. Bachmann M, Waibler Z, Pleli T, Pfeilschifter J and Mühl H. Type I interferon supports inducible nitric oxide synthase in murine hepatoma cells and hepatocytes and during experimental acetaminophen-induced liver damage. Front Immunol. 2017 Jul 31;8:890. doi: 10.3389/fimmu.2017.00890. eCollection 2017.

  20. Koch A, Grammatikos G, Trautmann S, Schreiber Y, Thomas D, Bruns F, Pfeilschifter J, Badenhoop K, and Penna-Martinez M. Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients. Int J Mol Sci. 18(7), pii: E1532. doi: 10.3390/ijms18071532. PubMed PMID: 28714882, 2017

  21. Hinrichsen I, Weßbecher IM, Huhn M, Passmann S, Zeuzem S, Plotz G, Biondi RM, and Brieger A. Phosphorylation-dependent signaling controls degradation of DNA mismatch repair protein PMS2. Mol Carcinog., doi: 10.1002/mc.22709. [Epub ahead of print] PubMed PMID: 28767177, 2017 (in press)

  22. Hess R, Wujak L, Hesse C, Sewald K, Jonigk D, Warnecke G, Fieguth H-G, de Maat S, Maas C, Bonella F, Preissner KT, Weiss B, Schaefer L, Kuebler W, Markart P, and Wygrecka M. Coagulation factor XII regulates inflammatory responses in human lungs. Thromb Haemost., 117(10): 1896-1907, 2017

  23. Schwalm S, Beyer S, Frey H, Haceni R, Grammatikos G, Thomas D, Geisslinger G, Schaefer L, Huwiler A, and Pfeilschifter J. Sphingosine kinase-2 deficiency ameliorates kidney fibrosis by up-regulating Smad7 in a mouse model of unilateral ureteral obstruction.Am J Pathol, 187: 2413-2429, 2017

  24. Nastase MV, Janicova A, Roedig H, Hsieh LTH, Wygrecka M, and Schaefer L. Small leucine-rich proteoglycans in renal inflammation: two sides of the coin. J Histochem Cytochem, 2017 (in press)

  25. Vienken H, Mabrouki N, Grabau K, Claas RF, Rudowski A, Schömel N, Pfeilschifter J, Lütjohann D, van Echten-Deckert G, and Meyer Zu Heringdorf D. Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca(2+) storage. Sci Rep., 7: 43575. doi: 10.1038/srep43575, 2017

  26. Richter C, Herrero San Juan M, Weigmann B, Bergis D, Dauber K, Muders MH, Baretton GB, Pfeilschifter JM, Bonig H, Brenner S, and Radeke HH. Defective IL-23/IL-17 Axis Protects p47phox-/- Mice from Colon Cancer. Front Immunol., 8:44. doi: 10.3389/fimmu.2017.00044. eCollection 2017, 2017

  27. Aglan A, Longen S, Dehne N, Köhler Y, Hassan M, Beck M, Tredup C, Boosen M, Hsieh TL, Schaefer L, Beck KF, and Pfeilschifter J. Nitric oxide mediates prolyl hydroxylase 3 expression in mesangial cells and in glomerulonephritis. J Mol Med (Berl)., 95(3):257-271, 2017

  28. Bonvin P, Gueneau F, Buatois V, Charreton-Galby M, Lasch S, Messmer M, Christen U, Luster AD, Johnson Z, Ferlin W, Kosco-Vilbois M, Proudfoot A, and Fischer N. Antibody Neutralization of CXCL10 in Vivo Is Dependent on Binding to Free and Not Endothelial-bound Chemokine: IMPLICATIONS FOR THE DESIGN OF A NEW GENERATION OF ANTI-CHEMOKINE THERAPEUTIC ANTIBODIES. J Biol Chem., 10; 292(10): 4185-4197, 2017

  29. Honke N, Shaabani N, Teijaro JR, Christen U, Hardt C, Bezgovsek J, Lang PA, and Lang KS. Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8(+) T Cells. Front Immunol., 8: 113. doi: 10.3389/fimmu.2017.00113. eCollection 2017, 2017

  30. Oertel S, Scholich K, Weigert A, Thomas D, Schmetzer J, Trautmann S, Wegner MS, Radeke HH, Filmann N, Brüne B, Geisslinger G, Tegeder I, and Grösch S. Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity. Cell Mol Life Sci., 74(16): 3039-3055, 2017

  31. Schmidt K, Herrero San Juan M, Trautmann S, Berninger L, Schwiebs A, Ottenlinger F, Thomas D, Zaucke F, Pfeilschifter JM, and Radeke HH. Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study. Front Immunol, 2017 (in press)

  32. Frevert CW, Felgenhauer J, Wygrecka M, Nastase MV, and Schaefer L. Danger associated molecular patterns from the extracellular matrix provide temporal control of innate immunity. J Histochem Cytochem, 2017 (in press)

  33. Wujak L, Böttcher R, Pak O, Frey H, El Agha E, Chen Y, Schmitt S, Bellusci S, Schaefer L, Weissmann N, Fässler R, and Wygrecka M. Low Density Lipoprotein Receptor-related Protein 1 Couples β1 Integrin Activation to Degradation. Cell Mol Life Sci, 2017 (in press)

  34. Hermann A, Wennmann DO, Gromnitza S, Edeling M, van Marck V, Sudol M, Schaefer L, Duning K, Weide T, Pavenstädt H, and Kremerskother J. WWC proteins regulate hepatic cell differentiation and tumorigenesis via the Hippo signaling pathway. Hepathology, 2017 (in press)

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