Publications 2015

  1. Beck KF, Euler J, Eisel F , Beck M, Köhler Y, Sha LK, von Knethen A, Longen S, and Pfeilschifter J. Cytokines induce protein kinase A-mediated signalling by a redox-dependent mechanism in rat renal mesangial cells. Biochem Pharmacol., 93(3): 362-9, 2015

  2. Hintermann E, Bayer M, Pfeilschifter JM, Deak F, Kiss I, Paulsson M, and Christen U. Upregulation of matrilin-2 expression in murine hepatic stellate cells during liver injury has no effect on fibrosis formation and resolution. Liver Int., 35(4): 1265-73, 2015

  3. Neil T, Schaefer L, and Iozzo RV Decoding the matrix: Instructive roles of proteoglycan receptors Biochemistry, 54(30): 4583-98, 2015

  4. Doller A, Badawi A, Schmid T, Brauß T, Pleli T , Meyer zu Heringdorf D, Piiper A, Pfeilschifter J, and Eberhardt W. The cytoskeletal inhibitors latrunculin A and blebbistatin exert antitumorigenic properties in human hepatocellular carcinoma cells by interfering with intracellular HuR trafficking. Exp Cell Res., 1;330(1):66-80, 2015

  5. Fuchs S, Hsieh LT, Saarberg W, Erdelmeier CAJ, Schaefer L, Koch E, and Fürst R. Haemanthus coccineus extract and its main bioactive component narciclasine display profound anti-inflammatory activities in vitro and in vivo. J Cell Mol Med, 19: 1021-32, 2015

  6. Neill T, Schaefer L, and Iozzo RV. Oncosuppressive functions of decorin. Mol Cell Oncol, 2(3):e975645, doi: 10.4161/23723556.2014.975645. eCollection 2015 Jul-Sep. Review. PubMed PMID: 27308453; PubMed Central PMCID: PMC4905288. 2015

  7. Ihlefeld K, Vienken H, Claas RF, Blankenbach K, Rudowski A, Ter Braak M, Koch A, Van Veldhoven PP, Pfeilschifter J, and Meyer Zu Heringdorf D. Upregulation of ABC transporters contributes to chemoresistance of sphingosine-1-phosphate lyase-deficient fibroblasts.J Lipid Res., 56(1): 60-69, 2015

  8. Helling B, König M, Dälken B, Engling A, Krömer W, Heim K, Wallmeier H, HaasJ, Wildemann B, Fritz B, Jonuleit H, Kubach J, Dingermann T, Radeke HH, OsterrothF, Uherek C, Czeloth N, and Schüttrumpf J. A specific CD4 epitope bound bytregalizumab mediates activation of regulatory T cells by a unique signalingpathway. Immunol Cell Biol., 93(4): 396-405, 2015

  9. Grammatikos G, Ferreiros N, Bon D, Schwalm S, Dietz J, Berkowski C, Fitting D, Herrmann E, Zeuzem S, Sarrazin C, and Pfeilschifter J. Variations in serum sphingolipid levels associate with liver fibrosis progression and poor treatment outcome in HCV but not HBV infection. Hepatology. 61(3): 812-22, 2015

  10. Biyanee A, Ohnheiser J, Singh P, and Klempnauer KH. A novel mechanism for the control of translation of specific mRNAs by tumor suppressor protein Pdcd4: inhibition of translation elongation. Oncogene, 34(11): 1384-92, 2015

  11. Wünsche C, Koch A, Goldschmeding R, Schwalm S, Meyer zu Heringdorf D, Huwiler A, and Pfeilschifter J. Transforming growth factor beta2 (TGF-beta2)-induced connective tissue growth factor (CTGF) expression requires sphingosine 1-phosphate receptor 5 (S1P5) in human mesangial cells. BBA - Molecular and Cell Biology of Lipids, 1851(5), 519-526, 2015

  12. Wujak L, Didiasova M, Frey H, Schaefer L, and Wygrecka M. Heparan sulfate proteoglycans mediate Factor XIIa binding to the cell surface. J Biol Chem, 290(11): 7027-39, 2015

  13. Scheiermann P, Bachmann M, Härdle L, Pleli T, Piiper A, Zwissler B, Pfeilschifter J, and Mühl, H. Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injury. Sci Rep., 5: 8521, 2015

  14. Koch A, Jäger M, Völzke A, Grammatikos G, Meyer zu Heringdorf D, Huwiler A, and Pfeilschifter JM. Downregulation of sphingosine 1-phosphate (S1P) receptor 1 by dexamethasone inhibits S1P-induced mesangial cell migration. Biol Chem., 396(6-7): 803-12, 2015

  15. Iozzo RV, Schaefer L: Proteoglycan form and function: A comprehensive nomenclature of proteoglycans. Matrix Biol, 42: 11-55, 2015

  16. Thangaraj G, Christophel J, Bachmann G, Greif A, and Layer, PG. PEDF counteracts DL-α-aminoadipate toxicity and rescues gliotoxic damages in RPE-free chicken retinal explants. Exp Eye Res., 134: 111-2, 2015

  17. Theocharis AD, Skandalis SS, Neill T, Multhaupt HA, Hubo M, Frey H, Gopal S, Gomes A, Afratis N, Lim HC, Couchman JR, Filmus J, Ralph D S, Schaefer L, Iozzo RV, and Karamanos NK. Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. Biochim Biophys Acta, 1855: 276-300, 2015

  18. Bryant CE, Gay NJ, Heymans S, Sacre S, Schaefer L, and Midwood KS: Advances in Toll-like Receptor biology: Modes of activation by diverse stimuli. Crit Rev Biochem Mol Biol, 10: 1-21, 2015

  19. Awwad K, Hu J, Shi L, Mangels N, Abdel Malik R, Zippel N, Fisslthaler B, Eble JA, Pfeilschifter J, Popp R, Fleming I. Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis. Cardiovasc Res., 106(2): 284-94, 2015

  20. Steinmeyer N, Doller A, Biyanee A, Brauß T, Schmid T, Pfeilschifter J, and Eberhardt W. Lymphotoxin alpha, a novel target of posttranscriptional gene regulation by HuR in HepG2 cells. FEBS Lett., 589(15): 1943-50, 2015

  21. Ohnheiser J, Ferlemann E, Haas A, Müller JP, Werwein E, Fehler O, Biyanee A, and Klempnauer KH. Programmed cell death 4 protein (Pdcd4) and homeodomain-interacting protein kinase 2 (Hipk2) antagonistically control translation of Hipk2 mRNA. Biochim Biophys Acta, 1853(7): 1564-73, 2015

  22. Schwalm S, Timcheva TM, Filipenko I, Ebadi M, Hofmann LP, Zangemeister-Wittke U, Pfeilschifter J, and Huwiler A. Sphingosine kinase 2 deficiency increases proliferation and migration of renal mouse mesangial cells and fibroblasts. Biol Chem, 396(6-7): 813-25, 2015

  23. Brunkhorst R, Friedlaender F, Ferreirós N, Schwalm S, Koch A, Grammatikos G, Toennes S, Foerch C, Pfeilschifter J, and Pfeilschifter W. Alterations of the Ceramide Metabolism in the Peri-Infarct Cortex Are Independent of the Sphingomyelinase Pathway and Not Influenced by the Acid Sphingomyelinase Inhibitor Fluoxetine. Neural Plast., 2015: 503079, 2015.

  24. Berner A, Bachmann M, Pfeilschifter J, Kraiczy P, and Mühl H. Interferon-α curbs production of Interleukin-22 by human peripheral blood mononuclear cells exposed to live Borrelia burgdorferi. J Cell Mol Med, 19(10): 2507-2511, 2015

  25. Burkhardt U, Beyer S, and Klein J. Role of phospholipases D1 and 2 in astroglial proliferation: effects of specific inhibitors and genetic deletion. Eur J Pharmacol., 761: 398-404, 2015

  26. Urtz N, Gaertner F, von Bruehl ML, Chandraratne S, Rahimi F, Zhang L, Orban M, Barocke V, Beil J, Schubert I, Lorenz M, Legate KR, Huwiler A, Pfeilschifter J, Beerli C, Ledieu D, Persohn E, Billich A, Baumruker T, Mederos Y, Schnitzler M, and Massberg S. Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro And In Vivo. Circ Res., 117: 376-387, 2015

  27. Gubbiotti MA, Neill T, Frey H, Schaefer L, and Iozzo RV. Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy. Matrix Biol., 48:14-25, 2015

  28. Härdle L, Bachmann M, Bollmann F, Pautz A, Schmid T, Eberhardt W, Kleinert H, Pfeilschifter J, and Mühl, H. Tristetraprolin regulation of interleukin-22 production. Sci Rep., 5: 15112, 2015.

  29. Stammler D, Eigenbrod T, Menz S, Frick JS, Sweet JM, Kelly GM, Jantsch J, Siegert I, Wölfle S, Julian D. Langer JD, Oehme I, Schaefer L, Heeg K, Dalpke AH, and Bode KA. Inhibition of histone deacetylases permits LPS-mediated secretion of bioactive IL-1? via a caspase-1-independent mechanism. J Immunol., 195: 5421-31, 2015.

  30. Grammatikos G, Ferreiròs N, Waidmann O, Bon D, Schroeter S, Koch A, Herrmann E, Zeuzem S, Kronenberger B, and Pfeilschifter J. Associate with Hepatic Decompensation and Survival in Patients with Cirrhosis. PLoS One. 2015 Sep 18;10(9):e0138130.

  31. Imeri F, Blanchard O, Jenni A, Schwalm S, Wünsche C, Zivkovic A, Stark H, Pfeilschifter J, and Huwiler A. FTY720 and two novel butterfly derivatives exert a general anti-inflammatory potential by reducing immune cell adhesion to endothelial cells through activation of S1P(3) and phosphoinositide 3-kinase. Naunyn Schmiedebergs Arch Pharmacol. 388(12): 1283-92, 2015.

  32. Lasch S, Müller P, Bayer M, Pfeilschifter JM, Luster AD, Hintermann E, and Christen U. Anti-CD3/anti-CXCL10 antibody combination therapy induces a persistent remission of type 1 diabetes in two mouse models. Diabetes, 64(12): 4198-211, 2015.

  33. Wagner A, Köhm M, Nordin A, Svenungsson E, Pfeilschifter JM, and Radeke HH. Increased Serum Levels of the IL-33 Neutralizing sST2 in Limited Cutaneous Systemic Sclerosis. Scand J Immunol. 82(3): 269-274, 2015.

  34. Pfarr K, Danciu C, Arlt O, Neske C, Dehelean C, Pfeilschifter JM, and Radeke HH. Simultaneous and dose dependent melanoma cytotoxic and immune stimulatory activity of betulin. PLoS One. 10(3)e0118802, 2015.

  35. Schröder M, Arlt O, Schmidt H, Huwiler A, Angioni C, Pfeilschifter JM, Schwiebs A, and Radeke HH. Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application. Biol Chem., 396(6-7): 795-802, 2015.

  36. Syhr KM, Boosen M, Hohmann SW, Longen S, Köhler Y, Pfeilschifter J, Beck KF, Geisslinger G, Schmidtko A, and Kallenborn-Gerhardt W. The H(2)S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain. Brain Res., 1624: 380-9, 2015.

  37. Olesch C, Sha W, Angioni C, Sha LK, Açaf E, Patrignani P, Jakobsson PJ, Radeke HH, Grösch S, Geisslinger G, von Knethen A, Weigert A, and Brüne B. MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer. Oncotarget, 6(12): 10284-96, 2015.

  38. Christen U, Hintermann E. An Update on Animal Models of Autoimmune Hepatitis: Are we There Yet? Curr Pharm Des., 21(18): 2391-400, 2015.

  39. Biyanee A, Singh P, and Klempnauer KH. Translation, Pdcd4 and eIF4A. Oncoscience. 2(9): 731-2, 2015.

  40. Danciu C, Oprean C, Coricovac DE, Andreea C, Cimpean A, Radeke H, Soica C, and Dehelean C. Behaviour of four different B16 murine melanoma cell sublines: C57BL/6J skin. Int J Exp Pathol., 96(2): 73-80., 2015.

  41. Meyer Dos Santos S, Blankenbach K, Scholich K, Dörr A, Monsefi N, Keese M, Linke B, Deckmyn H, Nelson K, Harder S. Platelets from flowing blood attach to the inflammatory chemokine CXCL16 expressed in the endothelium of the human vessel wall. Thromb Haemost., 114(2): 297-312, 2015.

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