Publications 2014

  1. Brunkhorst R, Vutukuri R, and Pfeilschifter W. Fingolimod for the treatment of neurological diseases-state of play and future perspectives. Front Cell Neurosci. 8: 283, 2014

  2. Schwalm S, Pfeilschifter J, and Huwiler A. Targeting the Sphingosine Kinase / Sphingosine 1-Phosphate Pathway to Treat Chronic Inflammatory Kidney Diseases. Basic Clin Pharmacol, 114(1): 44-49, 2014

  3. Völzke A, Koch A, Meyer Zu Heringdorf D, Huwiler A, und Pfeilschifter J. Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells. Biochim Biophys Acta, 1841(1): 11-21, 2014

  4. Zeng-Brouwers J, Beckmann J, Nastase MV, Iozzo RV, and Schaefer L. De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88/TRIF pathways. Matrix Biol, 35: 132-142, 2014

  5. Goyal A, Neill T, Owens RT, Schaefer L, and Iozzo RV. Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells. Matrix Biol, 35: 42-53, 2014

  6. Morcavallo A, Buraschi S, Xu S-Q, Belfiore A, Schaefer L, Iozzo RV, and Morrione A. Decorin differentially modulates the activity of insulin receptor isoform A ligands. Matrix Biol, 35: 82-90, 2014

  7. Ungerer C, Quade-Lyssy P, Radeke HH, Henschler R, Königs C, Köhl U, Seifried E, and Schüttrumpf J. Galectin-9 Is a Suppressor of T and B Cells and Predicts the Immune Modulatory Potential of Mesenchymal Stromal Cell Preparations. Stem Cells, 23(7): 755-766, 2014

  8. Waidmann O, Kronenberger B, Scheiermann P, Köberle V, Mühl H, and Piiper A. Interleukin 22 serum levels are a negative prognostic indicator in patients with hepatocellular carcinoma. Hepatology, 59(3): 1207, 2014

  9. Longen S, Woellhaf MW, Petrungaro C, Riemer J, and Herrmann JM. The disulfide relay of the intermembrane space oxidizes the ribosomal subunit mrp10 on its transit into the mitochondrial matrix. Dev Cell, 28(1): 30-42, 2014

  10. Moreth K, Frey H, Hubo M, Zeng-Brouwers J, Nastase MV, Hsieh L T-H, Haceni R, Pfeilschifter J, Iozzo RV, and Schaefer L. Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury. Matrix Biol, 35: 143–151, 2014

  11. Nastase MV, Iozzo RV, and Schaefer L. Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology. Biochim Biophys Acta, 1840: 2460-2470, 2014

  12. Anders HJ, Schaefer L. Beyond Tissue Injury--Damage-Associated Molecular Patterns, Toll-Like Receptors, and Inflammasomes Also Drive Regeneration and Fibrosis. J Am Soc Nephrol, 25(7): 1387-1400, 2014

  13. Grammatikos G, Mühle C, Ferreiros N, Schroeter S, Bogdanou D, Schwalm S, Hintereder G, Kornhuber J, Zeuzem S, Sarrazin C, and Pfeilschifter J. Serum acid sphingomyelinase is upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease. Biochim Biophys Acta, 1841(7): 1012-1020, 2014

  14. Schürmann C, Goren I, Linke A, Pfeilschifter J, and Frank S. Deregulated unfolded protein response in chronic wounds of diabetic ob/ob mice: A potential connection to inflammatory and angiogenic disorders in diabetes-impaired wound healing.
    Biochem Biophys Res Commun, 446(1): 195-200, 2014

  15. Winkler C, Doller A, Imre G, Badawi A, Schmid T, Schulz S, Steinmeyer N, Pfeilschifter J, Rajalingam K, and Eberhardt W. Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L. Cell Death & Disease, 5:e1321, 2014

  16. Schaefer L. Proteoglycans, key regulators of cell–matrix dynamics. Matrix Biol, 35: 1-2, 2014

  17. Bender C, Schlosser M, Christen U, Ziegler GA, and Achenbach P. GAD autoantibody affinity in schoolchildren from the general population. Diabetologia, 57(9): 1911-1918, 2014

  18. Christen U and Hintermann E. Pathogen infection and autoimmune hepatitis. Int Rev Immunol, 33(4): 296-313, 2014

  19. Christen, U. Pathogen infection and autoimmunity. Int Rev Immunol, 33(4): 261-265, 2014

  20. Burkhardt U, Stegner D, Hattingen E, Beyer S, Nieswandt B, Klein J. Impaired brain development and reduced cognitive function in phospholipase D-deficient mice. Neurosci Lett., 572C: 48-52, 2014

  21. Imeri F, Fallegger D, Zivkovic A, Schwalm S, Enzmann G, Blankenbach K, Meyer Zu Heringdorf D, Homann T, Kleuser B, Pfeilschifter J, Engelhardt B, Stark H, and Huwiler A. Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice. Neuropharmacology. 85: 314-327, 2014

  22. Neill T, Schaefer L, and Iozzo RV. Pathogen infection and autoimmunity. Instructive Roles of Extracellular Matrix on Autophagy. Am J Pathol 184: 2146-53, 2014

  23. Schürmann C, Schmidt N, Seitz O, Pfeilschifter J, and Frank S. Angiogenic response pattern during normal and impaired skin flap re-integration in mice: A comparative study. J Craniofac Surg,42(8): 1710-1716, 2014

  24. Hsieh LT, Nastase MV, Zeng-Brouwers J, Iozzo RV, and Schaefer L. Soluble biglycan as a biomarker of inflammatory renal diseases.Int J Biochem Cell Biol 54C: 223-235, 2014

  25. Arlt O, Schwiebs A, Japtok L, Rüger K, Katzy E, Kleuser B, and Radeke HH. Sphingosine-1-phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo. Cell Physiol Biochem., 34(1): 27-44, 2014

  26. Rüger K, Ottenlinger F, Schröder M, Zivković A, Stark H, Pfeilschifter JM, and Radeke HH. Modulation of IL-33/ST2-TIR and TLR signaling pathway by fingolimod and analogs in immune cells. Scand J Immunol., 80(6): 398-407, 2014

  27. Goren I, Pfeilschifter J, and Frank S. Uptake of Neutrophil-Derived Ym1 Protein Distinguishes Wound Macrophages in the Absence of Interleukin-4 Signaling in Murine Wound Healing.Am J Pathol., 184(12): 3249-61, 2014

  28. Bingold TM, Just L, Cuca C, Zacharowski K, Mönch C, Mühl H, Wissing H, Pipa G, Rosenberger P, Bechstein WO, Paulus P, Scheller B. Preoperative interleukin-22 values add valuable information for outcome prediction following orthotopic liver transplantation: a preliminary study. Ann Transpl. 19: 503-512, 2014

  29. Schaefer L. Complexity of danger: The diverse nature of damage-associated molecular patterns. J Biol Chem, 289(51): 35237-35245, 2014

  30. Pastukhov O, Schwalm S, Römer I, Zangemeister-Wittke U, Pfeilschifter J, and Huwiler A.Ceramide kinase contributes to proliferation but not to prostaglandin E2 formation in renal mesangial cells and fibroblasts. Cell Physiol Biochem, 34(1): 119-33, 2014

  31. Pastukhov O, Schwalm S, Zangemeister-Wittke U, Fabbro D, Bornancin F, Japtok L, Kleuser B, Pfeilschifter J, and Huwiler A. The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death. Br J Pharmacol., 171(24): 5829-5844, 2014

  32. Poluzzi C, Casulli J, Goyal A, Mercer TJ, Neill T, and Iozzo RV. Endorepellin evokes autophagy in endothelial cells. J Biol Chem, 289(23): 16114-16128, 2014

  33. Bollmann F, Art J, Henke J, Schrick K, Besche V, Bros M, Li H, Siuda D, Handler N, Bauer F, Erker T, Behnke F, Mönch B, Härdle L, Hoffmann M, Chen CY, Förstermann U, Dirsch VM, Werz O, Kleinert H, Pautz A. Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity. Nucleic Acids Res., 42(20): 12555-69, 2014

  34. Mauf S, Penna-Martinez M, Jentzsch T, Ackermann H, Henrich D, Radeke HH, Brück P, Badenhoop K, and Ramos-Lopez E. Immunomodulatory effects of 25-hydroxyvitamin D(3) on monocytic cell differentiation and influence of vitamin D(3) polymorphisms in type 1 diabetes. J Steroid Biochem Mol Biol., 147C:17-23, 2014

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Sekretariat Prof. Dr. Josef Pfeilschifter

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