Publications 2011

1. Hoegl S, Bachmann M, Scheiermann P, Goren I, Hofstetter C, Pfeilschifter J, Zwissler B, and Mühl H. Protective properties of inhaled IL-22 in a model of ventilator-induced lung injury. Am J Respir Cell Mol Biol, 44(3):369-76, 2011

2. Osman B, Akool ES, Doller A, Müller R, Pfeilschifter J, and Eberhardt W. Differential modulation of the cytokine-induced MMP-9/TIMP-1 protease-antiprotease system by the mTOR inhibitor rapamycin. Biochem Pharmacol, 81(1):1200-7, 2011

3. Schaefer L. Small leucine-rich proteoglycans in kidney disease. J Am Soc Nephrol, 22:1200-1207, 2011

4. Mühl H and Pfeilschifter J. Pharmakogenetik and Pharmakogenomik von Methotrexat: Aktuelle Bestandsaufnahme und neue Aspekte. Z Rheumatol, 70(2):101-7, 2011

5. Doberstein K, Schramme A, Lee BS, Blaheta RA, Wedel S, Moch H, Schraml P, Pfeilschifter J, Kristiansen G and Gutwein P. L1-CAM expression in ccRCC correlates with shorter patients survival times and confers chemoresistance in renal cell carcinoma cells. Carcinogenesis, 32(3):262-70, 2011

6. Mühl H, Bachmann M and Pfeilschifter J. Inducible NO synthase and antibacterial host defense
in times of Th17/Th22/T22 immunity. Cell Microbiol, 13(3):340-8, 2011

7. Ter Braak M, Claas RF, Hegen B, Labocha S, Ferreirós N, Pfeilschifter J, Huwiler A, van Echten-Deckert G, Meyer Zu Heringdorf D. Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator, Biochem Pharmacol, 81(5):617-25, 2011

8. Seitz O, Schürmann C, Hermes N, Müller E, Pfeilschifter J, Frank S, and Goren I. Wound healing in mice with high-fat diet- or ob gene-induced diabetes-obesity syndromes: A comparative study, Exp Diabetes Research, doi:10.1155/2010/476969, 2011

9. Huwiler A, Kotelevets N, Xin C, Pastukhov O, Pfeilschifter J, Zangemeister-Wittke U.
Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage. Brit J Pharmacol, 162(2):532-43, 2011

10. Scheiermann P, Beiras-Fernandez A, Mutlak H, and Weis F. The protective effects of levosimendan on ischemia/reperfusion injury and apoptosis. Recent Pat Cardiovasc Drug Discov, 6(1):20-6, 2011

11. Scheiermann P, Ott J, Hoegl S, Hecker M, Hofstetter C,  Seeger W, Zwissler B, Bausch B, Boost KA, and Mayer K. Effects of short-term infusion of lipid emulsions on pro-inflammatory cytokines and lymphocyte apoptosis in septic and non-septic rats. Brit J Nutr, 106(1):27-32, 2011

12. Scheiermann P, Hoegl S, Hofstetter C, Pfeilschifter J, Zwissler B, Mühl H, Boost KA, and Bertram Scheller. Comparing hemodynamics, blood gas analyses and proinflammatory cytokines in endotoxemic and severely septic rats. Int. Immunpharmacol, 11(6):719-23, 2011

13. Doller A, Winkler C, Azrilian I, Schulz S, Hartmann S, Pfeilschifter J, Eberhardt W. High constitutive HuR phosphorylation at Ser 318 by PKC{delta} propagates tumor relevant functions in colon carcinoma cells. Cacrinogenesis, 32(5):676-85, 2011

14. Korfei M, Schmitt S, Ruppert C, Henneke I, Markart P, Loeh B, Mahavadi P, Wygrecka M, Klepetko W, Fink L, Bonniaud P, Preissner KT, Lochnit G, Schaefer L, Seeger W, Guenther A: Comparative Proteomic Analysis of Lung Tissue from Patients with Idiopathic Pulmonary Fibrosis (IPF) and Lung Transplant Donor Lungs. J Proteom Res, 10:2185-205, 2011

15. Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I. SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature, 471 (7340):637-41, 2011

16. Bihrer V, Friedrich-Rust M, Kronenberger B, Forestier N, Haupenthal J, Shi Y, Peveling-Oberhag J, Radeke HH, Sarrazin E, Zeuzem S, Waidmann O, and Piiper A. Serum miR-122 as a biomarker of necroinflammation in patients with chronic hepatitis C virus infection. Am J Gastroenterol ., 106:1663-1669; doi:10.1038/ajg.2011.161, 2011

17. Christen U and von Herrath MG. Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference? Cell Mol Immunol, 8(3):193-8, 2011

18. Christen S, Holdener M, Beerli C, Thoma G, Bayer M, Pfeilschifter JM, Hintermann E, Zerwes HG, and Christen U. Small molecule CXCR3 antagonist NIBR2130 has only a limited impact on type 1 diabetes in a virus-induced mouse model. Clin Exp Immunol, 165(3):318-28, 2011

19. Rosenkranz AC, Rauch BH, Doller A, Eberhardt W, Böhm A, Bretschneider E, and Schrör K. Regulation of human vascular protease-activated receptor-3 through mRNA stabilisation and the transcription factor NFAT. Mol Pharmacol, 80(2): 337-44, 2011

20. Melchior-Becker A, Dai G, Ding Z, Schaefer L, Schrader J, Young MF, and Fischer JW. Deficiency of biglycan causes cardiac fibroblasts to differentiate into a myofibroblast phenotype. J Biol Chem, 286:17365-75, 2011

21. Schröder M, Richter C, Juan MH, Maltusch K, Giegold O, Quintini G, Pfeilschifter JM, Huwiler A,and Radeke HH. The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen. Mol Immunol, 48 (9-10):1139-48, 2011

22. Thompson J, Wilson P, Brandewie K, Taneja D, Schaefer L, Mitchell B, and Tannock LR. Renal Accumulation of Biglycan and Lipid Retention Accelerates Diabetic Nephropathy, Am J Pathol, 179:1179-87, 2011

23. Lee SB, Doberstein K, Baumgarten P, Wieland A, Ungerer C,  Bürger C, Hardt K,  Boehncke WH,  Pfeilschifter J, Mihic-Probst D,  Mittelbronn M and  Gutwein P. PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells. PLoS One. 6(8):e22312, 2011

24. Jobi K, Rauch BH, Dangwal S, Freidel K, Eberhardt W, Fischer JW, Schrör K, Doller A, Rosenkranz AC. Redox-Regulation of human protease-activated receptor-2 by activated factor X. Free Radic Biol Med. , 51(9):1758-64, 2011

25. Patra C, Diehl F, Ferrazzi F, van Amerongen MJ, Novoyatleva T, Schaefer L, Mühlfeld C, Jungblut B, Engel FB. Nephronectin regulates via BMP4-HAS2 signaling the differentiation of the atrio-ventricular canal in zebrafish. Development, 138:4499-509, 2011

26. Hintermann E, Holdener M, Bayer M, Loges S, Pfeilschifter JM, Granier C, Manns MP, Christen U. Epitope spreading of the anti-CYP2D6 antibody response in patients with autoimmune hepatitis and in the CYP2D6 mouse model. J Autoimmun. 37(3):242-53, 2011.

27. Doberstein K, Pfeilschifter J, Gutwein P. The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma. Carcinogenesis, 32(11):1713-23, 2011

28. Kern M, Winkler C, and Simon J. Respiratory nitrogen metabolism and nitrosative stress defence in ϵ-proteobacteria: the role of NssR-type transcription regulators. Biochem Soc Trans, 39(1):299-302, 2011

29. Brehm C, Huenecke S, Quaiser A, Esser R, Bremm M, Kloess S, Soerensen J, Kreyenberg H, Seidl C, Becker P, Mühl H, Klingebiel T, Bader P, Passweg JR, Schwabe D, and Koehl U. IL-2 Stimulated but Not Unstimulated NK Cells Induce Selective Disappearance of Peripheral Blood Cells: Concomitant Results to a Phase I/II Study. PLoS One, 6(11):e27351, 2011

30. Popovic ZV, Wang S, Papatriantafyllou M, Kaya Z, Porubsky S, Meisner M, Bonrouhi M, Burgdorf S, Young MF, Schaefer L, and Gröne HJ. The proteoglycan biglycan enhances antigen-specific T cell activation potentially via MyD88 and TRIF pathways and triggers autoimmune perimyocarditis. J Immunol 187:6217-26, 2011

31. Pankonien I, Alvarez JL, Doller A, Köhncke C, Rotte D, Regitz-Zagrosek V, Morano I, and Haase H. Ahnak1 is a tuneable modulator of cardiac Ca(v)1.2 calcium channel activity. J Muscle Res Cell Motil 32(4-5):281-90, 2011

32. Pfeilschifter W, Spitzer D, Pfeilschifter J, Steinmetz H, and Foerch C. Warfarin Anticoagulation Exacerbates the Risk of Hemorrhagic Transformation after rt-PA Treatment in Experimental Stroke: Therapeutic Potential of PCC. PLoS One, 6(10): e26087, 2011

33. Pfeilschifter W, Czech-Zechmeister B, Sujak M, Foerch C, Wichelhaus TA, and Pfeilschifter J. Treatment with the immunomodulator FTY720 does not promote spontaneous bacterial infections after experimental stroke in mice. Exp Transl Stroke Med., 3:2, 2011

34. Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhão JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, and Schaefer L. Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and miR-21. Sci Signal. 4, ra75, 2011, Summary, Abstract, Reprint, Full Text

35. Bihrer V, Waidmann O, Friedrich-Rust M, Forestier N, Susser S, Haupenthal J, Welker M, Shi Y, Peveling-Oberhag J, Polta A, von Wagner M, Radeke HH, Sarrazin C, Trojan J, Zeuzem S, Kronenberger B, and Piiper A. Serum MicroRNA-21 as Marker for Necroinflammation in Hepatitis C Patients with and without Hepatocellular Carcinoma PloS One, 6(10):e26971, 2011

36. Pfeilschifter W, Czech-Zechmeister B, Sujak M, Mirceska A, Koch A, Rami A, Steinmetz H, Foerch C, Huwiler A, and Pfeilschifter J. Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia. Biochem Biophys Res Commun. 413(2):212-7, 2011

37. Oberoi TK, Dogan T, Hocking JC, Scholz RP, Mooz J, Anderson CL, Karreman C, Meyer zu Heringdorf D, Schmidt G, Ruonala M, Namikawa K, Harms GS, Carpy A, Macek B, Köster RW, and Rajalingam K. IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. EMBO J, 31(1):14-28, 2011

38. Seitz O, Dehner JF, Schürmann C, Landes c, Frank S, Schlee M, and Sader R. Periimplantitis: Fakten und Visionen. Der MKG-Chirurg, 2011/4: DIO:10.1007/s12285-010-0176-0, 2011

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