Publications 2009

1. Scheiermann P, Hoegl S, Revermann M, Ahluwalia D, Zander J, Boost KA, Nguyen T, Zwissler B, Mühl H, and Hofstetter C. Cecal ligation and incision. An acute model of severe sepsis in rats. J Surg Res, 151(1), 132-137, 2009

2. Mulders AC, Mathy MJ, Meyer Zu Heringdorf D, Ter Braak M, Hajji N, Olthof DC, Michel MC, Alewijnse AE, and Peters SL. Activation of sphingosine kinase by muscarinic receptors enhances NO-mediated and attenuates EDHF-meiated vasorelaxation. Basic Res Cardiol, 104(1): 50-59, 2009

3. Schürmann C, Seitz O, Klein C, Sader R, Pfeilschifter J, Mühl H, Goren I, and Frank S. Tight spatial and temporal control in dynamic basal to distal migration of epithelial inflammatory responses and infiltration of cytoprotective macrophages determine healing skin flap transplants in mice. Ann Surg, 249(3): 519-534, 2009

4. König B, Koch A, Spielmann J, Hilgenfeld C, Hirche F, Stangl GI, and Eder K. Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1. Eur J Pharmacol, 605(1-3): 23-30, 2009

5. Hoegl S, Boost KA, Czerwonka H, Dolfen A, Scheiermann P, Mühl H, Zwissler B, and Hofstetter C. Inhaled IL-10 reduces biotrauma and mortality in a model of ventilator-induced lung injury. Resp Med, 103(3): 463-470, 2009

6. Schramme A, Oh ST, Stark A, Tilgen W, Gutwein P, and Reichrath J. The disintegrin-metalloproteinases ADAM10, ADAM12 and ADAM17 are upregulated in invading peripheral tumor cells of basal cell carcinomas. J Cutan Pathol, 36(4): 395-401, 2009

7. Goren I, Müller E, Schiefelbein D, Gutwein P, Seitz O, Pfeilschifter J, and Frank S. Akt1 controls insulin-driven VEGF biosysnthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice. J Invest Dermatol, 129(3): 752-764, 2009

8. Gutwein P, Schramme A, Sinke N, Abdel-Bakky MS, Voss B, Obermüller N, Doberstein K, Koziolek M, Fritzsche F, Johannsen M, Jung K, Schaider H, Altevogt P, Ludwig A, Kristiansen G, and Pfeilschifter J. Tumoral CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients. European Journal of Cancer, 45(3): 478-489, 2009

9. Giegold O, Ludwig RJ, Hardt K, Will J, Schön MP, Oostingh GJ, Pfeilschifter JM, Boehncke WH, and Radeke HH. Computer-aided analysis of cell interactions under dynamic flow conditions. Exp Dermatol, 18: 238-245, 2009

10. Jespersen C, Doller A, Akool ES, Bachmann M, Müller R, Gutwein P, Mühl H, Pfeilschifter J, and Eberhardt W. Molecular mechanisms of nitric oxide-dependend inhibition of TPA-induced matrix metalloproteinase-9 (MMP-9) in MCF-7 cells. J Cell Physiol, 219(2): 276-287, 2009

11. Alban S, Ludwig RJ, Bendas G, Schön MP, Oostingh GJ, Radeke HH, Fritzsche J, Pfeilschifter J, Kaufmann R, and Boehncke WH. PS3, a semisynthetic beta-1,3-glucan sulfate, diminishes contacthypersensitivity responses through inhibition of L- and P-Selectin functions. J Invest Dermatol, 129(5): 1192-1202, 2009

12. Doller A, Gauer S, Sobkowiak E, Geiger H, Pfeilschifter J, and Eberhardt W. Angiotensin II enhances renal PAI-1 and COX-2 expression posttranscriptionally by activating the mRNA-stabilizing factor HuR. implications for hypertensive nephrosclerosis. Am J Pathol, 174(4): 1252-1263, 2009

13. Gutwein P, Schramme A, Voss B, Abdel-Bakky MS, Doberstein K, Ludwig A, Altevogt P, Hansmann ML, Moch H, Kristiansen G, and Pfeilschifter J. Downregulation of Junctional adhesion molecule-A is involved in the progression of clear cell renal cell carcinoma. Biochem Biophys Res Commun, 380(2): 387-391, 2009

14. Königshoff M, Wilhelm J, Jahn A, Amarie OV, Kramer M, Kitowska K, Wilhelm A, Bohle RM, Obert M, Traupe H, Seeger W, Rose F, Fink L, Schaefer L, Günther A, and Eickelberg O. WISP, a matricellular protein of the CCN family, is a novel mediator of pulmonary fibtrosis. J Clin Invest, 119: 772-787, 2009

15. Richter C, Juan MH, Will J, Brandes RP, Kalinke U, Akira S, Pfeilschifter JM, Hultqvist M, Holmdahl R, and Radeke HH. Ncf1 provides a reactive oxygen species-independent negative feedback regulation of TLR9-induced IL-12p70 in murine dendritic cells. J Immunol, 182(7): 4183-4891, 2009

16. Appel S, Vetterkind S, Koplin A, Maertens B, Boosen M, and Preuss U. EFP1 is an ER stress-induced glycoprotein which interacts with the pro-apoptotic protein Par-4. Cell Health and Cytoskeleton, 1: 1-16, 2009

17. Nieuwenhuis B, Lüth A, Chun J, Huwiler A, Pfeilschifter J, Schäfer-Korting M, and Kleuser B. Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P(3) in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone. J Mol Med, 87: 645-657, 2009

18. Gutwein P, Abdel-Bakky MS, Schramme A, Doberstein K, Kämpfer-Kolb N, Amann K, Hauser IA, Obermüller N, Bartel C, Abdel-Aziz A, El Sayed E, and Pfeilschifter J. CXCL16 is expressed in podocytes and acts as a scavenger receptor for oxidized LDL. Am J Pathol, 2009 (in press)

19. Riedle S, Kiefel H, Gast D, Bondong S, Wolterink S, Gutwein P, and Altevogt P. Nuclear translocation and signaling of L1-CAM in human carcinoma cells requiresADAM10 and presenilin/ secretase activity. Biochem J, 2009 (in press)

20. Goren I, Allmann N, Yogev N, Schürmann C, Linke A, Holdener M, Waisman A, Pfeilschifter J, and Frank S. A transgenic mouse model of inducible macrophage depletion: effects of diphteria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic and contractive processes. Am J Pathol, 2009 (in press)

21. Scheiermann P, Ahluwalia D, Hoegl S, Dolfen A, Revermann M, Zwissler B, Mühl H, Boost KA, and Hofstetter C. Effects of intravenous and inhaled levosimendan in severe rodent sepsis. Intensive Care Med, 2009 (in press)

22. Ziesché E, Scheiermann P, Bachmann M, Sadik CD, Hofstetter C, Zwissler B, Pfeilschifter J, and Mühl H. Dexamethasone suppresses IL-22 associated with bacterial infection in vitro and in vivo. Clin Exp Immunol, 2009 (in press)

23. Sadik CD, Bachmann M, Pfeilschifter J, and Mühl H. Activation of interferon regulatory factor-3 via Toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA. Nucleic Acids Res, 37(15):5041-56, 2009

24. Arafa HM, Hemeida RA, Hassan MI, Abdel-Wahab MH, Badary OA, and Hamada FM. Basic acetyl-1-carnitine ameliorates caerulein-induced acute pancreatitis in rats. Basic Clin Pharmacol, 2009 (in press)

25 Dreieicher E, Beck KF, Lazaroski S, Boosen M, Tsalastra-Greul W, Beck M, Fleming I, Schäfer L, and Pfeilschifter J. Nitric oxide inhibits glomerular TGB-beta signaling via SMOC-1. J Am Soc Nephrol, 2009 (in press)

26. Osipova-Goldberg HI, Turchanowal LV, Adler B, and Pfeilschifter JM. H2O2 inhibits BCR-dependent immediate early induction of EBV genes in Burkitts lymphoma cells. Free Rad Bio Med, 2009 (in press)

27. Ren S, Babelova A, Moreth K, Xin C, Eberhardt W, Doller A, Pavenstädt H, Schaefer L, Pfeilschifter J, and Huwiler A. The TGF-beta-induced CTGF expression is under suppressive control of sphingosine kinase-1 in podocytes in vitro and in vivo. Kidney Int, 2009 (in press)

28. Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, Bruckner P, Pfeilschifter J, Schaefer RM, Gröne HJ, and Schaefer L. Biglycan: a danger signal that activates the NLRP3 inflammasome via Toll-like and P2X receptors. J Biol Chem, 2009 (in press)

29. Gutgesell A, Wen G, König B, Koch A, Spielmann J, Stangl GI, Eder K, and Ringseis R. Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells. Biochim Biophys Acta, 2009 (in press)

30. Boosen M, Vetterkind S, Kubicek J, Scheidtmann KH, Illenberger S, and Preuss U. Par-4 is an essential downstream target of Dlk in Dlk/Par-4-mediated apoptosis. Mol Biol Cell, 2009 (in press)

31. Czech B, Pfeilschifter W, Omrani NM, Strobel MA, Kahles T, Neumann-Haefelin T, Rami A, Huwiler A, and
Pfeilschifter J.
The immunomodulatory sphingosine 1-phosphate analoge FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia. Biochem Biophys Res Commun, 389(2): 251-256, 2009

32. Zhang G, Breuer M, Förster A, Egger-Adam D, and Wodarz A. Mars, a Drosophila protein related to vertebrate HURP, is required for the attachment of centrosomes to the mitotic spindle during syncytial nucler divisions. J Cell Sci., 122(pt4): 535-545, 2009

33. Zhu X, De Laurentis W, Leang K, Herrmann J, Ihlefeld K, van Pee KH, and Naismith JH. Structural insights into the regioselectivity in the enzymatic chlorination of trypthphan. J Mol Biol, 391(1): 74-85, 2009

34. Rückrich T, Kraus M, Gogel J, Beck A, Ovaa H, Verdoes M, Overkleeft HS, Kalbacher H, and Driessen C. Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells. Leukemia, 23(6): 1098-1105, 2009

35. Grillet N, Xiong W, Reynolds A, Kazmierczak P, Sato T, Lillo C, Dumont RA, Hintermann E, Sczaniecka A, Schwander M, Williams D, Kachar B, Gillespie PG, and Müller U. Harmonin mutations cause mechanotransduction defects in cochlear hair cells. Neuron, 62(3): 375-387, 2009

36. Merline R, Schaefer R, and Schaefer L. The matricellular functions of small leucine-rich proteoglycans (SLRPs). J Cell Com Signal, 3: 323-335, 2009

37. Merline R, Lazaroski S, Babelova A, Tsalastra-Greul W, Pfeilschifter J, Schlüter KD, Günther A, Iozzo RV, Schaefer RM, and Schaefer L. Decorin deficiency in diabetic mice: Aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear infiltration. J Physiol Pharmacol 60, Suppl 4, 2009

38. ter Braak M, Danneberg K, Lichte K, Liphardt K, Ktistakis NT, Pitson SM, Hla T, Jakobs KH, and Meyer zu Heringdorf D. Galphaq-mediated plasma membrane translocation of sphingosine kinase-1and cross-activation of S1P receptors. Biochim Biophys Acta, 1791(5): 357-370, 2009

39. Pushparaj PN, Manikandan J, Tay HK, H`ng SC, Kumar S, Pfeilschifter J, Huwiler A, and Melendez AJ. Sphingosine Kinase 1 is pivotal for FcepsilonRI-mediated mast cell signaling and functional responses in vitro and in vivo. J Immunol, 183(1): 221-227, 2009

40. Osman B, Doller A, Akool ES, Holdener M, Hintermann E, Pfeilschifter J, and Eberhardt W. Rapamycin induces the TGFb/Smad signaling cascade in renal mesangial cells upstream of mTOR. Cell Signal, 21(12): 1806-1817, 2009

41. Ludwig RJ, Hardt K, Hatting M, Bistrian R, Diehl S, Radeke HH, Podda M, Schön MP, Kaufmann R, Henschler R, Pfeilschifter JM, Santoso S, Boehncke WH. Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha4beta1 integrin. Immunology, 128(2): 196-205, 2009

42. Pfeilschifter W, Neumann-Haefelin T, Hattingen E, and Singer OC. Kortikale Venenthrombose nach diagnostischer Lumbalpunktion. Der Nervenarzt, 80(10):1219-1221, German, 2009

43. Balah A, Akool ES, Bachmann M, Pfeilschifter J, and Mühl H. The dsRNA mimetic poly(I:C) and IL-18 synergize for IFNgamma and TNFalpha expression. Biochem Biophys Res Commun, 389(4): 628-633, 2009

44. Bachmann M, Paulukat J, Pfeilschifter J, and Mühl H. Molecular mechanisms of IL-18BP regulation in DLD-1 cells: pivotal direct action of the STAT1/GAS axis on the promoter level. J Cell Mol Med, 13(8b): 1987-1994, 2009
45. Christen U, Hintermann E, and Jaeckel E. New animal models for autoimmune hepatitis. Semin Liver Dis, 29(3): 262-272, 2009

46. Horwitz MS, Efrat S, Christen U, von Herrath MG, and Oldstone MB. Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes. Proc Natl Acad Sci USA, 106(46): 19450-19454

47. Wicker S, Pfeilschifter JM, and Gottschalk, R. Gesundheit von Studierenden der Medizin. Zentralblatt für Arbeitsmedizin, 8: 234-241, German, 2009

48. Huwiler A and Pfeilschifter J. Lipids as targets for novel anti-inflammatory therapies. Pharmacol Ther, 124(1):96-112, 2009

49. Boost KA, Leipold T, Scheiermann P, Hoegl S, Sadik CD, Hofstetter C, and Zwissler B. Sevoflurane and isoflurane decrease TNF-alpha-induced gene expression in human monocytic THP-1 cells: potential role of intracellular IkappaBalpha regulation. Int J Mol Med. 23(5): 665-71, 2009

50. Bergthaler A, Flatz L, Verschoor A, Hegazy AN, Holdener M, Fink K, Eschli B, Merkler D, Sommerstein R, Horvath E, Fernandez M, Fitsche A, Senn BM, Verbeek JS, Odermatt B, Siegrist CA, Pinschewer DD. Impaired antibody response causes persistence of prototypic T cell-contained virus. PLoS Biol. 7(4): e1000080, 2009

51. Gutwein P, Abdel-Bakky MS, Doberstein K, Schramme A, Beckmann J, Schäfer L, Amann K, Doller A, Kämpfer-Kolb N, Abdel-Aziz A, El Sayed E, and Pfeilschifter J. CXCL16 and oxLDL are induced in the onset of diabetic nephropathy. J Cell Mol Med, 13(9B), 3809-38254, 2009

52. Schramme A, Oh ST, Tilgen W, Gutwein P, and Reichrath J. Overexpression of CXCL16 in lesional psoriatic skin. Dermato-Endocrinology, 1(2):114-118, 2009

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