Publications 2008

1. Lichte K, Rossi R, Danneberg K, ter Braak M, Kürschner U, Jakobs KH, Kleuser B, and Meyer zu Heringdorf D. Lysophospholipid receptor-mediated calcium signaling in human keratinocytes. J Invest Dermatol, 1, 1-12, 2008

2. Fink K, Zellweger R, Weber J, Manjarrez-Orduno N, Holdener M, Senn BM, Hemgartner H, Zinkernagel RM, and Macpherson AJ. Long-term maternal imprinting of the specific B cell repertoire by maternal antibodies. Eur J Immunol, 38: 90-101, 2008

3. Daniel C, Sartory NA, Zahn N, Radeke HH, and Stein J. Immunomodulatory treatment of TNBS colitis with calcitriol is associated with a change of Th1/Th17 to Th2 and regulatory T- cell profile. J Pharmacol Exp Ther, 324(1): 23-33, 2008

4. Cevikbas F, Schaefer L, Uhlig P, RobenekH, Theilmeier G, Echtermeyer F, and Bruckner P. Unilateral nephrectomy leads to upregulation of syndecan-2 and TGF-beta mediated glomerulosclerosis in syndecan-4 deficient mice. Matrix Biol, 27(1): 42-52, 2008

5. Johann AM, Weigert A, Eberhardt W, Kuhn A-M, Barra V, von Knethen A, Pfeilschifter J, and Brüne B. Apoptotic cell derived S1P promotes HuR-dependent COX-2 mRNA stabilization and protein expression. J Immunol, 180(2): 1239-1248, 2008

6. Conen A, Weisser M, Orasch JC, Battagay M, Trampuz A, Frei R, Christen S, Heim D, Gratwohl A, and Flückiger U. Candida krusei - a serious complication in patients with hematological malignancies: successful treatment with caspofungin. Transpl Infect Dis, 10(1): 66-70, 2008

7. Hoegl S, Boost KA, Flondor M, Scheiermann P, Muhl H, Pfeilschifter J, Zwissler B, Hofstetter C. Short-term exposure to high-pressure ventilation leads to pulmonary biotrauma and systemic inflammation in the rat. Int J Mol Med, 21(4): 513-519, 2008

8. Rubant SA, Ludwig RJ. Diehl S, Hardt K, Kaufmann R. Pfeilschifter JM, and Boehncke WH. Dimethylfumarate reduces leukocyte rolling in vivo through modulation of adhesion molecule expression. J Invest Dermatol, 128(2): 326-331, 2008

9. Westermann D, Mersmann J, Melchior A, Petrik C, Freudenberger T, Lettau O, Schaefer L, Lüllmann-Rauch R, Jacoby C, Schrader J, Brand-Herrmann SM, Young MF, Levkau B, Babba H, Unger T, Zacharowski K, Tschöpe C, and Fischer JW. Biglycan is required for adaptive remodelling after myocardial infarction. Circulation, 117(10): 1269-1276, 2008

10. Schwalm S, Graf F, Römer I, Bubnova S, Pfeilschifter J, and Huwiler A. Sphingosine kinase-1 is a hypoxia-regulated gene that regulates migration of human endothelial cells. Biochem Biophys Res Commun, 368(4): 1020-1025, 2008

11. Doller A, Akool ES, Huwiler A, Müller R, Radeke HH, Pfeilschifter J, and Eberhardt W. Posttranslational modification of the AU-rich element binding protein HuR by PKCdelta elicits angiotensin II-induced stabilization and nuclear export of COX-2 mRNA. Mol Cell Biol, 28(8): 2608-2625, 2008

12. Poleganov MA, Bachmann M, Pfeilschifter J, and Mühl H. Genome-wide analysis displays marked induction of EBI3/IL-27B in IL-18-activated AML-derived KG1 cells: Critical role of two kappaB binding sites in the human EBI3 promotor. Mol Immunol, 45(10): 2869-2880, 2008

13. Koch A, König B, Stangl GI, Eder K. PPAR alpha mediates transcriptional upregulation of novel organic cation transporters-2 and -3 and enzymes involved in hepatic carnitine synthesis. Exp Biol Med (Maywood), 233(3): 356-365, 2008

14. König B, Koch A, Giggel K, Dordschbal B, Eder K, Stangl GI. Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha. Biochim Biophys Acta, 1780(6): 899-904, 2008

15. Lastres-Becker, I., Brodesser, S., Lütjohann, D., Azizov, M., Buchmann, J., Hintermann, E., Sandhoff, K., Schürmann, A., Nowock, J., Auburger, G. Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice. Hum Mol Genet. 15: 1465-1481, 2008

16. Janot L, Secher T, Torres D, Maillet I, Pfeilschifter J, Quesniaux VFJ, Landmann, R, Ryffel B, and Erard F. CD14 with Toll-like receptor 2 contributes to recognition and control of Listeria monocytogenes infection. J Infect Dis, 2008 (in press)

17. Huwiler A and Pfeilschifter J. New player on the center stage: sphingosine 1-phosphate and its receptors as drug targets. Biochem Pharmacol, 2008 (in press)

18. Schramme A, Abdel-Bakky MS, Kämpfer-Kolb N, Pfeilschifter J, and Gutwein P. The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells. Biochem Biophys Res Commun, 2008 (in press)

19. Schramme A, Abdel-Bakky MS, Gutwein P, Obermüller N, Baer PC, Hauser IA, Ludwig A, Gauer S, Schäfer L, Sobkowiak E, Altevogt P, Koziolek M, Kiss E, Gröne HJ, Tikkanen R, Goren I, Radeke HH, and Pfeilschifter J. Characterization of CXCL16 and ADAM10 in the normal and transplanted kidney. Kidney Int, 2008 (in press)

20. Oh ST, Schramme A, Stark A, Tilgen W, Gutwein P, and Reichrath J. Overexpression of ADAM10 and ADAM12 in lesional psoriatic skin. Br J Dermatol, 2008 (in press)

21. Schiefelbein D, Goren I, Fißlthaler B, Schmidt H, Geisslinger G, Pfeilschifter J, Frank S. Biphasic regulation of HMG CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses. J Biol Chem, 2008 (in press)

22. Sadik CD, Hunfeld KP, Bachmann M, Kraiczy P, Eberhardt W, Brade V, Pfeilschifter J, and Mühl H. Systematic analysis highlights the key role of TLR2/NFkappaB/MAP kinase signaling for IL-8 induction by macrophage-like THP-1 cells under influence of B.burgdorferi lysates. Int J Biochem Cell Biol, 2008 (in press)

23. Schaefer L, Iozzo RV. Biological functions of the Small leucine-rich proteoglycans: From genetics to signal transduction. J Biol Chem, 2008 (in press)

24. Holdener, M., Hintermann, E., Bayer, M., Rhode, A., Rodrigo, E., Hintereder, G., Johnson, E.F., Gonzalez, F.J., Pfeilschifter, J., Manns, M.P., von Herrath, M.G., and Christen, U. Breaking tolerance to the natural human liver autoantigen Cytochrome P450 2D6 by virus infection. J Exp Med, 2008 (in press)

25. Akool ES, Doller A, Babelova A, Tsalastra W, Moreth K, Schaefer L, Pfeilschifter J, and Eberhardt W. Molecular mechanisms of TGFb-receptor-triggered signalingn cascades rapidly induced by the calcineurin inhibitors cyclosphorine and FK506. J Immunol, 181(4): 2831-2845, 2008

26. Goren I, Müller E, Pfeilschifter, and Frank S. Thr308 determines Akt1 nuclear localization in insulin-stimulated keratinocytes. Biochem Biophys Res Commun, 372(1): 103-107, 2008

27. Duning K, Schurek EM, Schlüter M, Bayer M, Reinhardt HC, Schwab A, Schaefer L, Benzing T, Saleem MA, Kremerskothen J, Weide T, and Pavenstädt H. KIBRA is involved in cell polarity, migration and adhesion of podocytes. J Am Soc Nephrol, 19: 1891-1903, 2008

28. Doller A, Pfeilschifter J, and Eberhardt, W. Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR. Cell Signal, 20(12): 2165-2173, 2008

29. Boost KA, Sadik CD, Bachmann M, Zwissler B, Pfeilschifter J, and Mühl H. IFNgamma impairs release of IL-8 by IL-1beta stimulated A549 lung carcinoma cells. BMC Cancer, 8: 265, 2008

30. Schielfelbein D, Seitz O, Goren I, Dißmann JP, Schmidt H, Bachmann M, Sader R, Geisslinger G, Pfeilschifter J, and Frank S. Keratinocyte-derived VEGF biosynthesis represents a pleiotropic side effect of PPARgamma agonist troglitazone but not rosiglitazone and involves activation of p38 MAPK: implications for diabetes-impaired skin repair. Mol Pharmacol, 74(4): 952-963, 2008

31. Hofmann LP, Ren S, Schwalm S, Pfeilschifter J, and Huwiler A. Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner. Biol Chem, 389: 1399-1407, 2008

32. Wiesemann E, Deb M, Hemmer B, Radeke HH, and Windhagen A. Early identification of interferon-beta responders by ex vivo testing in patients with multiple sclerosis. Clin Immunol, 128(3): 306-313, 2008

33. Meyer zu Heringdorf. Lysophospholoipids. Encyclopedia of Molecular Pharmacology; Offermanns S,Rosenthal W (Eds); 2nd Edition, Springer-Verlag Heidelberg, 2008

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Sekretariat Prof. Dr. Josef Pfeilschifter

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