Publications 2007

1. Keller C, Rivera GiP, Tölle M, van der Giet M, Chun J, Radeke HH, Schäfer-Korting M, and Kleuser B. Immunmodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signalling. Am J Pathol, 170(1): 281-292, 2007

2. Waibler Z, Kalinke U, Will J, Herrero San Juan M, Pfeilschifter JM, and Radeke HH. TLR-ligand stimulated interleukin-23 subunit expression and assembly is regulated differentially in murine plasmacytoid and myeloid dendritic cells. Mol Immunol, 44(7): 1483-1489, 2007

3. Moreth K, Riester D, Hildmann C, Hempel R, Wegener D, Schober A, Schwienhorst A. An active site tyrosine residue is essential for amidohydrolase but not for esterase activity of a class 2 histone deacetylase-like bacterial enzyme. Biochem J, 401: 659-665, 2007

4. Bachmann M, Dragoi C, Poleganov MA, Pfeilschifter J, Mühl H. Interleukin-18 directly activates T-bet expression and function via p38-MAP kinase and NFkappaB in AML-derived Pre-dendritic KG-1 cells. Mol Cancer Ther, 6(2): 723-731, 2007

5. Daniel C, Sartory NA, Zahn N, Geisslinger G, Radeke HH, and Stein J. FTY720 ameriolates Th1-mediated colitis in mice by directly affecting the functional activity od CD4+CD25+ regulatory T-cells. J Immunol, 178(4): 2458-2468, 2007

6. Ramos-Lopez E, Brück P, Jansen T, Pfeilschifter JM, Radeke HH, and Badenhoop K. CYP2R1-, CYP27B1- and CYP24-mRNA expression in German type 1 diabetes patients. J Steroid Biochem Mol Biol, 103(3-5): 807-810, 2007

7. Buchhaupt M, Pfeifer C, and Entian KD. Analysis of 2`-O-methylated nucleosides and pseudouridines in ribosomal RNAs using DNAzymes. Anal Biochem, 361(1): 102-108, 2007

8. Schaefer L, Tsalastra W, Babelova A, Baliova M, Minneruo J, Sorokin L, Gröne HJ, Reinhardt DP, Pfeilschifter J, Iozzo RV, and Schaefer RM. Decorin-mediated regulation of fibrillin-1 in the kidney involves IGF-1 receptor and mTOR. Am J Pathol, 170(1): 301-315, 2007

9. Bedke J, Kiss E, Schaefer L, Behnes CL, Bonrouhi M, Gretz N, Horuk R, Diedrichs-Moehring M, Wildner G, Nelson PJ, and Gröne HJ. Beneficial effects of CCR1 blockade on the progression of chronic renal allograft-damage. Am J Transplant, 7(3): 527-537, 2007

10. Klawitter S, Hofmann LP, Pfeilschifter J, and Huwiler A. Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity. Br J Pharmacol, 150(3): 225-257, 2007

11. Stoeck A, Gast D, Sanderson MP, Issa Y, Gutwein P, Altevogt P. L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. Gynecol Oncol, 104(2): 461-469, 2007

12. Doller A, Akool ES, Müller R, Gutwein P. Kurowski C, Pfeilschifter J, and Eberhardt W. Molecular Mechanisms of cyclosporin A inhibition of the cytokine-induced matrix metalloproteinase-9 (MMP-9) in glomerular mesangial cells. J Am Soc Nephrol, 18(2): 581-592, 2007

13. Zhang C, Wenger T, Mattern J, Ilea S, Frey C, Gutwein P, Altevogt P., Bodenmuller W, Gassler N, Schnabel PA, Dienemann H, Marme A, Hohenfellner M, Haferkamp A, Pfitzenmaier J, Grone HJ, Kolb A, Buchler P, Buchler M, Friess H, Rittgen W, Edler L, Debatin KM, Krammer PH, Rutz HP, and Herr I. Clinical and Mechanistic Aspects of Glucocorticoid-Induced chemotherapy resitance in the majority of solid tumors. Cancer Biol Ther, 6(2): 278-287, 2007

14. Boost KA, Hoegl S, Hofstetter C, Flondor M, Stegewerth K, Platacis I, Pfeilschifter J, Mühl H, and Zwissler B. Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on Il-1b, IL-18 and downstream pro-inflammatory parameters as detected in rat ecdotoxaemia. Intensive care Med, 33(5): 863-871, 2007

15. Eberhardt W, Doller A, Akool ES, Pfeilschifter J. Modulation of mRNA stability as a novel therapeutic approach. Pharmacology & Therapeutics, 114(1): 56-73, 2007

16. Doller A, Huwiler A, Müller R, Radeke HH, Pfeilschifter J, and Eberhardt W. PKCalpha-dependend phosphorylation of the mRNA stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2. Mol Biol Cell, 18(6): 2137-2148, 2007

17. Ziesché E, Bachmann M, Kleinert H, Pfeilschifter J, Mühl H. The IL-22/STAT3 pathway potentiates expression of iNOS in human colon carcinoma cells. J Biol Chem, 282(22): 16006-16015, 2007

18. Döll F, Pfeilschifter J, and Huwiler A. Prolactin upregulates sphingosine kinase-1 expression and activity in the human breast cancer cell line MCF7 and triggers enhanced proliferation and migration. Endocrine-Related Cancer, 14(2): 325-335, 2007

19. Daniel C, Sartory NA, Zahn N, Schmidt R, Geisslinger G, Radeke HH, and Stein J. FTY720 ameliorates oxazolone-coliltis in mice by directly affecting T helper 2 functions. Mol Immunol, 44(13): 3305-3316, 2007

20. Eberhardt W and Pfeilschifter J. Nitric oxide and vascular remodeling: Spotlight on the kidney. Kidney Int Suppl, 106: S9-S16, 2007

21. Schacke W, Beck KF, Pfeilschifter J, and Hattenbach LO. Expression of ubiquitin carboxy-terminal hydrolase-11 in photocoagulated human retinal pigment epithelial cells. Curr Eye Res, 32(4): 367-372, 2007

22. Goren I, Müller E, Schiefelbein D, Christen U, Pfeilschifter J, Mühl H, and Frank S. Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages. J Invest Derm, 127(9):2259-2267, 2007

23. Luchtefeld M, Bandlow N, Tietge UJ, Grote K, Pfeilschifter J, Kaszkin M, Beck S, Drexler H, and Schieffer B. Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A(2)-dependent lipid peroxidation. Atherosclerosis, 194(1), 62-70, 2007

24. Gauer S, Sichler O, Obermüller N, Holzmann Y, Kiss E, Sobkowiak E, Pfeilschifter J, Geiger H, Mühl H, Hauser IA. IL-18 is expressed in the intercalated cell of human kidney. Kidney Int, 72(9): 1081-1087, 2007

25. Behrens F, Himsel A, Rehart S, Stanczyk J, Beutel B, Zimmermann SY, Köhl U, Moeller B, Gay S, Kaltwasser JP, Pfeilschifter JM, and Radeke HH. Imbalance in distribution of functional autologous regulatory T cells in rheumatoid arthritis. Annals of the Rheumatic Diseases, 66:1151-1156, 2007

26. Buchhaupt M, Kotter P, and Entian KD. Mutations in the nucleolar proteins Tma23 and Nop6 suppress the malfunction of the Nep1 protein. FEMS Yeats Res, 7(6): 771-781, 2007

27. Schaefer L, Schaefer RM. A primer on iron therapy. Nephrol Dial Transplant, 22(9): 2429-2431, 2007

28. Ulrich S, Huwiler A, Loitsch S, Schmidt H, and Stein JM. De novo ceramide biosysnthesis is associated with resveratrol-induced inhibition or ornithine decarboxylase activity. Biochem Pharmacol, 74(2): 281-289, 2007

29. Xin C, Ren S, Eberhardt W, Pfeilschifter J, and Huwiler A. Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta - induced prostaglandin E2 formation. J Lipd Res, 48(9), 1985-1996, 2007

30. Dwir O, Grabovski V, Pasvolsky R, Manevich E, Shamri R, Gutwein P, Feigelson SW, Altevogt P, and Alon R. Membranal cholestreol is not required for L-selectin adhesiveness in primary lymphocytes but controls a chemokine-induced destabilization of L-selectin rolling adhesions. J Immunol, 179(2): 1030-1038, 2007

31. Nold M, Nold-Petry C, Fischer D, Richter B, Blaheta R, Pfeilschifter J, Mühl H, Schranz D, and Veldman A. Activated protein C downregulates p38 mitogen-activated protein kinase and improves clinical parameters in an in vivo model of septic shock. Thrombosis and Haemostatsis, 98(5), 1118-1126, 2007

32. Keller S, Rupp C, Stoeck A, Runz S, Fogel M, Lugert S, Hager HD, Abdel-Bakky MS, Gutwein P, and Altevogt P. CD24 is a marker of exosomes secreted into urine and amniotic fluid. Kidney Int, 72(9), 1095-1102, 2007

33. Hintermann E and Christen U. Viral infection - a cure for type 1 diabetes? Cur Med Chem, 14: 2048-2052, 2007

34. Christen U and Hintermann E. Dual role of CXCL10 as conductor of cellular traficking during typ 1 diabetes. Int J Biomed Sci, 3: 86-92, 2007

35. Christen U, Holdener M, and Hintermann E. Animal models for autoimmune hepatitis. Autoimmune Rev, 6: 306-311, 2007

36. Christen U. Chemokines as drug targets intype 1 diabetes. Endocr Metab Immun Disord Drug Targets (Curr Drug Targezs), 7: 7-12, 2007

37. Martinic MM, Juedes AE, Bresson D, Homann D, Skak K, Huber C, Ling E, Ejrnares M, Wolfe T, Togher L, Christen U, and von Herrath, MG. Minimal impact of a de-novo expressed B-cell autoantigen on spontaneous diabetes development in NOD mice. Diabetes, 56: 1059-1068, 2007

38. Schneider D, Liaw L, Daniel C, Athanasopoulus AN, Herrmann M, Preissner KT, Nawroth PP, and Chavakis T. Inhibition of breasr cancer cell adhesion and bone metastasis by the extracellular adherence protein of Staphylococcus aureus. Biochem Biophys Res Com, 357(1), 282-288, 2007

39. Daniel C, Schroeder O, Zahn N, Steinhilber D, and Stein J. The TGFbeta-Smad 3-signalling pathway is involved in butyrate-mediated Vitamin D receptor expression. J Cell Biochem, 102(6), 1420-1431, 2007

40. Xin C, Ren S, Eberhardt W, Pfeilschifter J, and Huwiler A. FTY720 suppresses Interleukin -1beta induced secretory phospholipase A2 expression in renal mesangial cells by a transriptional mechanism. Br J Pharmacol, 150, 943-950, 2007

41. König B, Koch A, Spielmann J, Hilgenfeld C, Stangl GI, and Eder K. Activation of PPARalpha lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2. Biochem Pharmacol, 73(14), 574-585, 2007

42. Koch A, König B, Spielmann J, Leitner A, Stangl, GI and Eder K. Thermally oxidized oil increases the expression of insulin-induced genes and inhibits activation of sterol regulatory elememt-binding protein-2 in rat liver. J Nutr, 137(9), 2018-2023, 2007

43. Koch A, König B, Luci S, Stangl, GI, and Eder K. Dietary oxidzed fat up regulates the expression of organic cation transporters in liver and small intestine and alters carnitine concentrations in liver, muscle and plasma of rats. Br J Nutr, 98(5), 882-889, 2007

44. Hofstetter C, Boost KA, Flondor M, Basagan-Mogol E, Betz C, Homann M, Mühl H, Pfeilschifter J, Zwissler B. Anti-inflammatory effects of sevoflurane and mild hypothermia in endotoxemic rats. Acta Anaesthesiol Scand, 51(7), 893-899, 2007

45. Boost KA, Flondor M, Hofstetter C, Platacis I, Stegewerth K, Hoegl S, Nquyen T, Mühl H, Zwissler B. The beta-adrenoceptor antagonist propranolol counteracts anti-inflammatory effects of isoflurane in rat endotoxemia. Acta Anaesthesiol Scand, 51(7), 900-908, 2007

46. Hofstetter C, Boost KA, Hoegl S, Flondor M. Scheller B, Mühl H, Pfeilschifter J, Zwissler B. Norepinephrine and vasopressin counteract anti-inflammatory effects of isoflurane in endotoxemic rats. Int J Mol Med, 20(4), 597-604, 2007

47. Alemany R, van Koppen CJ, Danneberg K, Ter Braak M, and Meyer Zu Heringdorf D. Regulation and functional roles of sphingosine kinases. Naunyn Schmiedebergs Arch Pharmacol, 374(5-6), 413-428, 2007

48. Meyer Zu Heringdorf D, Jakobs KH. Renal mesangial cells: moving on sphingosine kinase-1. Br J Pharmacol, 150(3), 255-257, 2007

49. Meyer Zu Heringdorf D, Jakobs KH. Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism. Biochim Biophys Acta, 1768(4), 923-940, 2007

50. Mewes KR, Raus M, Bernd A, Zöller NN, Sättler A, and Graf R. Elastin expression in a newly developed full thickness skin equivalent. Skin Pharmacol Physiol, 20, 85-95, 2007

51. Poleganov MA, Pfeilschifter J, and Mühl H. Expanding extracellular zinc beyond levels reflecting the albumin-bound plasma zinc pool potentiates the capability of IL-1beta, IL-18, and IL-12 to act as IFNgamma-inducing factors on PBMC. J Interferon Cytokine Res, 27(12), 997-1002, 2007

52. Huwiler A and Zamgemeister-Wittke U. Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy. Crit Rev Oncol Hemat, 63(2): 150-159, 2007


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