Publications 2003

1. Beck GCh, Hermes WC, Yard BA, Kaszkin M, von Zabern D, Schulte J, Haak M, Prem K, Krimsky W, van Ackern K, van der Woude FJ, and Yedgar S. Amelioration of endotoxin-induced sepsis in rats by membrane anchored lipid conjugates. Crit Care Med 31, 2015-2021, 2003

2. Kämpfer H, Bräutigam L, Geisslinger G, Pfeilschifter J, and Frank S. Cyclooxygenase-1-coupled prostaglandin biosynthesis constitues an essential prerequisite for skin repair. J Invest Dermatol 120, 880-890, 2003

3. Beck GCh, Yard BA, Schulte J, Haak M, van Ackern K, van der Woude FJ, and Kaszkin M. Secreted phospholipases A2 induce the expression of chemokines in microvascular endothelium. Biochem Biophys Res Commun. 300, 731-737, 2003

4. Heese K., Beck KF, Behrens MH, Pluss K, Fierlbeck W, Huwiler A, Mühl H, Geiger H, Otten U, and Pfeilschifter J. Effects of high glucose on cytokine-induced nerve growth factor (NGF) expression in rat renal mesangial cells. Biochem Pharmacol 65, 293-301, 2003

5. Uhlenbrock K, Huber J, Ardati A, BuschAE and Kostenis E Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. Cell Physiol Biochem 13, 75-84, 2003

6. Bruch-Gerharz D, Schnorr O, Suschek C, Beck KF, Pfeilschifter J, Ruzicka T, and Kolb-Bachofen V. Arginase 1 overexpression in psoriasis: limitation of inducible nitric oxide synthase activity as a molecular mechanism for keratinocytes hyperproliferation. Am J Pathol 162, 203-211, 2003

7. Pfeilschifter J, Eberhardt W, Beck KF, and Huwiler A. Redox signaling in mesangial cells.
Nephron 93, 23-26, 2003

8. Madsen JT, Jansen P, Hesslinger C, Meyer M, Zimmer J and Gramsbergen JB. Tetrahydrobiopterin precursor sepiapterin provides protection against neurotoxicity of
1-methyl-4-phenylpyridinium in nigral slice cultures. J Neurochem 85(1):214-23, 2003

9. Möller B, Paulukat J, Nold M, Behrens MH, Kukoc-Zivojnov N, Kaltwasser JP, Pfeilschifter J, and Mühl H. Interferon-g induces expression of interleukin-18 binding protein in fibroblast-like synoviocytes. Rheumatology, 42, 442-445, 2003

10. Rölz W, Xin C, Ren S, Pfeilschifter J, and Huwiler A. Interleukin-1b inhibits ATP-induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramide. Br. J. Pharmacol 138, 461-468, 2003

11. Nold M, Goede A, Eberhardt W, Pfeilschifter J, and Mühl H. IL-18 initiates release of matrix metalloproteinase-9 from peripheral blood mononuclear cells without affecting tissue inhibitor of matrix metalloproteinases-1: Supression by TNFa blockage and modulation by IL-10. Naunyn-Schmiedeberg's Archives of Pharmacology 367, 68-75, 2003

12. Goren I, Pfeilschifter J, and Frank S. Determination of leptin signaling pathways in human
and murine keratinocytes. Biochem Biophys Res Commun. 303, 1080-1085, 2003

13. Gurrieri S, Fürstenberger G, Schadow A, Haas U, Singer AG, Ghomashchi F, Pfeilschifter J, Lambeau G, Gelb MH, and Kaszkin M. Differentiation-dependent regulation of secreted phospholipases A2 in murine epidermis. J Invest Dermatol 121:156-164, 2003

14. Nold M, Hauser IA, Höfler S, Goede A, Eberhardt W, Ditting T, Geiger H, Pfeilschifter J, and Mühl H. IL-18BPa:Fc cooperates with immunosuppressive drugs in human whole blood. Biochem Pharmacol 66, 505-510, 2003

15. Huwiler A, Ren Shuyu, Holthöfer Harry, Pavenstädt H, and Pfeilschifter J. Inflammtory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes. Biochem Biophys Res Commun. 305, 136-142, 2003

16. Failer BU, Aschrafi A, Schmalzing G, and Zimmermann H. Determination of native oligomeric state and substrate specificity of rat NTPDase1 and NTPDase2 after heterologous expression in Xenopus oocytes. Eur J Biochem 271, 1802-1809, 2003

17. Akool ES, Kleinert H, Hamada FMA, Abdelwahab MH, Förstermann U, Pfeilschifter J, and Eberhardt W. Nitric oxide increases the decay of MMP-9 mRNA by inhibiting the expression of mRNA stabilizing factor HuR. Mol Cell Biol 23, 4901-4916, 2003

18. Schaefer L, Beck KF, Raslik I, Walpen S, Mihalik D, Micegova M, Macakova K, Schonherr E, Seidler DG, Varga G, Schaefer RM, Kresse H, and Pfeilschifter J. Biglycan, a nitric oxide-regulated gene, affects adhesion, growth and survival of mesangial cells. J Biol Chem 278, 26227-26237, 2003

19. Deja M, Busch T, Bachmann S, Riskowski K, Campean V, Wiedmann B, Schwabe M, Hell B, Pfeilschifter J, Falke KJ, and Lewandowski K. Reduced nitric oxide in sinus epithelium of patients with radiologic maxillary sinusitis and sepsis. Am J Respir Crit Care Med 168(3):281-6, 2003

20. Gauer S, Hartner A, Hauser IA, Fierlbeck W, Eberhardt W, and Geiger H. Differential regulation of osteopontin expression in the clipped and nonclipped kidney of two-kidney, one-clip hypertensive rats. Am J Hypertens 16, 214-222, 2003

21. Mühl H and Pfeilschifter J. Anti-inflammatory properties of pro-inflammatory Interferon-g. Int Immunopharmacol 3, 1247-1255, 2003

22. Beck S, Lambeau G, Scholz-Pedretti K, Gelb MH, Janssen MJW, Edwards SH, Wilton DC, Pfeilschifter J, and Kaszkin M. Potentiation of TNFalpha-induced sPLA2-IIA expression in mesangial cells by an autocrine loop involving secreted phospholipase A2 and PPARalpha activation. J Biol Chem 278(32): 29799-29812, 2003

23. Huwiler A and Pfeilschifter J. Nitric oxide signalling with a special focus on lipid derived
mediators. Biol Chem 384(10-11):1379-89, 2003

24. Kämpfer H, Pfeilschifter J, and Frank S. Expression and activity of arginase isoenzymes
during normal and diabetes-impaired skin repair. J Invest Dermatol 121(6):1544-51, 2003

25. Aschrafi A, Franzen R, Shabahang S, Fabbro D, Pfeilschifter J, and Huwiler A. Ceramide induces translocation of protein kinase C-ato the Golgi compartment of human embryonic kidney cells by interacting with C2 domain. Biochim Biophys Acta 1634(1-2):30-9, 2003

26. Goren I, Kämpfer H, Podda M, Pfeilschifter J, and Frank S. Leptin and wound inflammation in diabetic ob/ob mice: differential regulation of neutrophil and macrophage influx and a potential role for the scab as a sink for inflammatory cells and mediators. Diabetes 52(11):2821-32, 2003

27. Mühl H and Pfeilschifter J. Endothelial nitric oxide synthase: a determinant of TNFa production by human monocytes/macrophages. Biochem Biophys Res Commun 310, 677-680, 2003

28. Kaszkin M and Loew D. Comparability of herbal medicinal products. Journal of the European Society of Regulatory AffairsMay/June Vol. 10, No. 3, 2003

29. Mühl H, Höfler S, and Pfeilschifter J. Inhibition of lipopolysaccharide/ATP-induced release of interleukin-18 by KN-62 and glyburide. Eur J Pharmacol 482(1-3):325-8, 2003

30. Huwiler A, Akool El-S, Aschrafi A, Hamada FM, Pfeilschifter J, and Eberhardt W. ATP potentiates IL-1b-induced MMP-9 expression in mesangial cells via recruitment of the ELAV protein HuR. J Biol Chem 278(51):51758-69, 2003

31. Pfeilschifter J, Eberhardt W, and Huwiler A. Nitric Oxide and Mechanisms of Redox Signaling. J Am Soc Nephrol 14, 237-240, 2003

32. Fichtlescherer S, Kaszkin M, Breuer S, Dimmler S, and Zeiher AM. Elevated secretory group II phospholipase A2 serum activity is assiciated with impaired endothelial vasodilator function in patients with coronary artery disease. Clin Sci (Lond) 2003 Dec 19

33. El-Gayar S, Thuring-Nahler H, Pfeilschifter J, Rollinghoff M, and Bogdan C. Translational control of inducible nitric oxide synthase by IL-13 and arginine availability in inflammatory macrophages. J Immunol 171, 4561-4568, 2003

34. Leckel K, Beecken WD, Jonas D, Oppermann E, Coman MC, Beck KF, Cinatl J, Hailer NP, Auth MK, Bechstein WO, Shipkova M, and Blaheta RA. The immunosuppressive drug mycophenolate mofetil impairs the adhesion capacity of gastrointestinal tumour cells. Clin Exp Immunol 134(2):238-45, 2003

35. Xu D, Falke D, and Juliano RL. P53-dependent cell-killing by selective repression of thymidine kinase and reduced prodrug activation. Mol Pharmacol 64(2):289-97, 2003

36. Falke D and Juliano RL. Selective gene regulation with designed transcription factors: implications for therapy. Curr Opin Mol Ther 5(2):161-6, 2003

37. Falke D, Fisher M, Ye D, and Juliano RL. Design of artificial transcription factors to selectively regulate the pro-apoptotic bax gene. Nucleic Acids Res 31(3):e10, 2003

38. Wolter F, Turchanowa L, and Stein J. Resveratrol-induced modification of polyamine metabolism is accompanied by induction of c-Fos. Carcinogenesis 24(3):469-74, 2003

39. Milovic V and Turchanowa L. Polyamines and colon cancer. Biochem Soc Trans 31(2):381-3, 2003

40. Mühl H and Pfeilschifter J. A short summary. The history of glucocorticoids. Pharm Unserer Zeit 32(4):284-7, 2003

41. Pfeilschifter J and Huwiler A. Inflammation. Encyclopedic Reference of Molecular Pharmacology, 2003

42. Eberhardt W and Kilz T. On genomic and nongenomic effects. Molecular basis of glucocorticoid action. Pharm Unserer Zeit 32(4):288-94, 2003

43. Frank S and Kämpfer H. Excisional wound healing. An experimental approach. Methods Mol Med 78:3-15, 2003

44. Gilchrist M, Hesslinger C, and Befus AD. Tetrahydrobiopterin, a Critical Factor in the Production and Role of Nitric Oxide in Mast Cells. J Biol Chem 278:50607-14, 2003

45. Raschke K, Shabahang M, and Wolf R. The slow and the quick anion conductance in whole guard cells: their voltage-dependent alternation, and the modulation of their activities by abscisic acid and CO2. Planta 217:639-50 (2003)

46. Keller T, Pleskova M, McDonald MC, Thiemermann C, Pfeilschifter J, and Beck KF.
Identification of manganese superoxide dismutase as a NO-regulated gene in rat glomerular mesangial cells by 2D gel electrophoresis. Nitric Oxide 9:183-193, 2003

47. Aschrafi A, Shabahang S, Pfeilschifter J, and Huwiler A. Regulatory functions of protein
kinase C isoenzymes in the kidney. Current Topics in Biochemical Research, Vol. 5, 2003

48. Shabahang S, Aschrafi A, Pfeilschifter J, and Huwiler A. Sphingolipids in Health and Disease. Recent Research Developments in Human Pathology, Vol. 1, 2003

49. Cornelissen G, Bertelsen HP, Lenz K, Hahn B, Schultz M, Scheffler U, Werner E, Leptien H, Krüß S, Jansen AK, Elsholz O, Gliem T, Wilhelm BU, Sowa E, Radeke HH, and Luttmann R. Production of recombinant proteins with Pichia pastoris in integrated processing. Engineering in Life Sciences, 3(9):361-370, 2003

50. Cornelissen G, Bertelsen HP, Hahn B, Schultz M, Scheffler U, Werner E, Leptien H, Krüß S, Jansen AK, Gliem T, Hielscher M, Wilhelm BU, Sowa E, Radeke HH, and Luttmann R. Herstellung rekombinanter Proteine mit Pichia pastoris in integrierter Prozessführung. Chemie Ingenieur Technik, 75(3):281-290, 2003

51. Lykke-Andersen K, Schaefer L, Menon S, Deng XW, Miller JB, Wei N. Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. Mol Cell Biol, 23(19): 6790-6797, 2003

52. Tralhão JG, Schaefer L, Micegova M, Evaristo C, Schönherr E, Kayal S, Veiga-Fernandes H, Danel C, Aresta S, Iozzo RV, Kresse H, Lemarchand P. In vivo selective and distant killing of cancer cells using adenovirus-mediated decorin gene transfer. FASEB J, 17(3): 464-466, 2003


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